ea0016p44 | Adrenal | ECE2008
Ueberberg Bianca
, Althoff Ricarda
, Deutschbein Timo
, Unger Nicole
, Hinrichs Jakob
, Walz Martin K
, Schmid Kurt W
, Petersenn Stephan
Background: The diagnosis of hyperaldosteronism is hindered by the absence of a well-defined gold-standard. CYP11B2 (aldosterone synthase) belongs to the steroid-metabolizing enzymes catalyzing the last step of the aldosterone synthesis. To establish a molecular marker for aldosterone-producing adenomas, we compared the expression in various adrenal tumors.Methods: Tissue from 20 aldosterone-producing adenomas (APA), 12 hyperplasias associated with hyper...